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EspañolnMost recent publications
Year
Publication
2015 Pérez-Gómez, E., Andradas, C., Caffarel, M.M., Blasco-Benito, S., García-Taboada, E., Villa-Morales, M., Moreno, E., Hamann, S., Martín-Villar, E., Flores, J.M., Wenners, A., Alkatout, I., Klapper, W., Röcken, C., Bronsert, P., Stickeler, E., Staebler, A., Bauer, M., Arnold, N., Soriano, J., Pérez-Martínez, M., Megías, D., Moreno-Bueno, G., Ortega- Gutiérrez, S., Artola, M., Vázquez-Villa, H., Quintanilla, M., Fernández-Piqueras, J., Canela, E.I., McCormick, P.J., Guzmán, M. & Sánchez, C. (2015) Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer. J. Natl. Cancer Inst. 107, djv077. 2,58MB
2015 Blázquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., García-Rincón, D., Sendtner, M., Timmusk, T., Lutz, B., Galve-Roperh, I., & Guzmán, M. (2015) The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ. (Epub) 2015 Garcez, P.P., Diaz-Alonso, J., Crespo-Enriquez, I., Castro, D., Bell, D., Guillemot, F.(2015) Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1. Nat. Commun. (Epub) 2015 Morales, P., Blasco-Benito, S., Andradas, C., Gómez-Cañas, M., Flores, J.M., Goya, P., Fernández-Ruiz, J.J., Sánchez,* C., & Jagerovic,* N. (*co-corresponding authors) (2015) A selective, non-toxic CB2 cannabinoid o-quinone with in vivo activity against triple negative breast cancer. J. Med. Chem. (Epub) 2015 Salazar, M., Lorente, M., García-Taboada, M., Pérez Gómez, E., Dávila, D., Zúñiga-García, P., Flores, J.M., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E. & Velasco, G. (2015) Loss of tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death Differ. 22, 131-144. 2014 Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P. & Harkany, T. (2014) Programming of neural cells by (endo-)cannabinoids: from physiological rules to emerging therapies. Nat. Rev. Neurosci. 15, 787-804. 2014 Moreno, E., Andradas, C., Medrano, M., Caffarel, M.M., Pérez-Gómez, E., Blasco-Benito, S., Gómez-Cañas, M., Pazos, M.R., Irving, A.J., Lluís, C., Canela, E.I., Javier Fernández-Ruiz, J., Guzmán, M., McCormick, P.J. & Sánchez, C. (2014) Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. J. Biol. Chem. 2014, 289, 21960-21972.
2014 Chiarlone, A., Bellocchio, L., Blázquez, C., Resel, E., Soria-Gómez, E., Cannich, A., Ferrero, J.J., Sagredo, O., Benito, C., Romero, J., Sánchez-Prieto, J., Lutz, B., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M. (2014) A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc. Natl. Acad. Sci. USA 111, 8257–8262.
2014 Díaz-Alonso, J., Aguado, T., de Salas-Quiroga, A., Ortega, Z., Guzmán, M. & Galve-Roperh, I. (2014) CB1 cannabinoid receptor-dependent activation of mTORC1/Pax6 signaling drives Tbr2 expression and basal progenitor expansion in the developing mouse cortex. Cereb. Cortex (Epub)
2014 Soria-Gómez, E., Bellocchio, L., Reguero, L., G. Lepouse, Martin, C., Bendahmane, M., Ruehle, S., Remmers, F., Desprèz, T., Matias, I., Wiesner, T., Cannich, A., Wadleigh, A., Pape, H.P., Chiarlone, A.P., Quarta, C., Verrier, D., Vincent, P., Massa, F., Lutz, B., Guzmán, M., Gurden, H., Ferreira, G., Lledo, P.M., Grandes, P. & Marsicano, G. (2014) The endocannabinoid system controls food intake via olfactory processes. Nat. Neurosci. 17, 407-415 2013 Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., Maccarrone, M. (2013) Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Prog. Lipid Res. 52, 633-650. 2013 Pérez-Gómez, E., Andradas, C., Flores, J.M., Quintanilla, M., Paramio, J.M., Guzmán, M. & Sánchez, C. (2013) The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas. Oncogene 32, 2534-2542. 2013 Casarejos, M.J., Perucho. J., Gómez, A., Muñoz, M.P., Fernández-Estévez, M., Sagredo, O., Fernández Ruiz, J., Guzmán, M., García de Yébenes, J. & Mena, M.A. (2013) Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. J. Alzheimers Dis. 35, 525–539 2013 Bellocchio, L., Soria-Gómez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E., Cannich, A., Delamarre, A., Häring, M., Martín-Fontecha, M., Vega, D., Bartsch, D., Monory, K., Lutz, B., Chaouloff, F., Pagotto, U., Guzmán, M., Cota, D. & Marsicano, G. (2013) Activation of the sympathetic nervous system mediates hypophagic and anxiety-related effects of CB1 receptor blockade. Proc. Natl. Acad. Sci. USA 110, 4786-4791. 2013 Campos, A.C., Ortega, Z., Palazuelos, J., Fogaça, M.V., Aguiar, D.C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Henar, S., Moreira F.A., Guzmán, M., Galve-Roperh, I. & Guimarães, F.S. (2013) The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int. J. Neuropsychopharmacol. 16, 1407-1419. 2013 Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Dávila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E. & Velasco, G. (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochim. Biophys. 1831, 1573-1578 2012 Díaz-Alonso, J., Aguado, T., Wu, C., Palazuelos, J., Hofmann, C. Garcez, P., Guillemot, F., Lu, H., Lutz, B., Guzmán, M. & Galve-Roperh, I. (2012) The CB1 Cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J. Neurosci. 32, 16651-16665. 2012 Bañez-Coronel, M., Porta, S., Kagerbauer, B., Mateu-Huertas, E., Pantano, L., Ferrer, I., Guzmán, M., Estivill, X. & Martí, E. (2012) A pathogenic mechanism in Huntington´s disease involves small CAG- Repeated RNAs with neurotoxic activity. PLoS Genet. 8. 2012 Velasco, G., Sánchez, C. & Guzmán, M. (2012) Towards the use of cannabinoids as antitumour agents. Nat. Rev. Cancer 12, 436-444. 2012 Caffarel, M., Andradas, C., Pérez-Gómez, E., Guzmán, M. & Sánchez,C. (2012) Cannabinoids: A new hope for breast cancer therapy?. Cancer Treat. Rev. 38, 911-918. 2012 Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. (2012) Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development. Philos Trans. R. Soc. Lond. B. Biol. Sci. 367, 3229-3241. 2012 Palazuelos, J., Ortega, Z., Díaz-Alonso, J., Guzmán, M. & Galve-Roperh, I. (2012) CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling. J. Biol. Chem. 287, 1198-1209.
2011 Henstridge, C.M., Balenga, N.A., Kargl, J., Andradas, C., Brown, A.J., Irving, A., Sanchez, C. & Waldhoer, M. (2011) Recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55. Mol. Endocrinol. 11, 1835-1848. 2011 Salazar, M., Hernández-Tiedra, S., Torres, S., Lorente, M., Guzmán, M. & Velasco, G. (2011) Detecting autophagy in response to ER stress signals in cancer. Methods Enzymol. 489, 297-317.
2011 Vara, D., Salazar, M., Olea-Herrero, N., Guzmán, M., Velasco, G. & Díaz-Laviada, I. (2011) Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ.18, 1099-1111. 2011 Lorente, M., Torres, S., Salazar, M., Carracedo, A., Hernández-Tiedra, S., Rodríguez-Fornés, F., García-Taboada, E., Meléndez, B., Mollejo, M., Campos-Martín, Y., Lakatosh, S.A., Barcia, J., Guzmán, M. & Velasco, G. (2011) Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy mediated cell death. Autophagy 7, 1071-1073.
2011 Lorente, M., Torres, S., Salazar. M., Carracedo, A., Hernández-Tiedra, S., Rodríguez-Fornés, F., García-Taboada, E., Meléndez, B., Mollejo, M., Campos-Martín, Y., Lakatosh, S.A., Barcia, J., Guzmán, M. & Velasco, G. (2011) Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ. 18, 959-973.
2011 Torres, S., Lorente, M., Rodríguez-Fornés, F., Hernández-Tiedra, S., Salazar. M., García-Taboada, E., Barcia, J., Guzmán, M. & Velasco, G. (2011) A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol. Cancer Ther. 10, 90-103.
2011 Blázquez, C., Chiarlone, A., Sagredo, O., Aguado, T., Pazos, M.R., Resel, E., Palazuelos. J., Julien, B., Salazar, M., Börner, C., Benito, C., Carrasco, C., Diez-Zaera, M., Paoletti, P., Díaz-Hernández, M., Ruiz, C., Sendtner, M., Lucas, J.J., De Yébenes, J.G., Marsicano, G., Monory, K., Lutz, B., Romero, J., Alberch, J., Ginés, S., Kraus, J., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M. (2011) Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain 134, 119-136. 2011 Andradas, C., Caffarel, M.M., Pérez-Gómez E., Salazar M. , Lorente M., Velasco G., Guzmán, M. & Sánchez C. (2011) The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK. Oncogene 30, 245-252.
2010 Caffarel, M.M , Andradas, C., Mira, E., Pérez-Gómez, E., Cerutti, C., Moreno-Bueno, G., Flores, J.M., García-Real, I., Palacios, J., Mañes, S., Guzmán, M. & Sánchez, C. (2010) Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol. Cancer 9, 196-197.
2010 Guzmán, M. (2010) A new age for MAGL. Chem. Biol. 17, 4-6. 2010 Barana, A., Amorós, I., Caballero, R., Gómez, R., Osuna, L., Lillo, M.P., Blázquez, C., Guzmán, M., Delpón, E. & Tamargo, J. (2010) Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner. Cardiovasc. Res. 85, 56-67. 2009 Palazuelos, J., Aguado, T., Pazos, M.R., Julien, B., Carrasco, C., Resel, E., Sagredo, O., Benito, C., Romero, J., Azcoitia, I., Fernández-Ruiz, J., Guzmán, M. & Galve-Roperh, I. (2009) Microglial CB2 cannabinoid receptors are neuroprotective in Huntington´s disease excitotoxicity. Brain 132, 3152-3164. 2009 Oesch, S., Walter, D., Wachtel, M., Pretre, K., Salazar, M., Guzmán, M., Velasco, G. & Schäfer, B.W. (2009) Cannabinoid receptor 1 is a potential drug targefor treatment of translocation-positive rhabdommyosarcoma. Mol. Cancer Ther. 8, 1838-1845. 2009 Lorente, M., Carracedo, A., Torres, S., Natali, F., Egia, A., Blázquez, C., Hernández, S., Guzmán, M. & Velasco, G. (2009) Amphiregulin renders glioma cells resistant to cannabinoid-induced apoptosis. Glia 57, 1374-1385. 2009 Galve-Roperh, I., Palazuelos, J., Aguado, T. & Guzmán, M. (2009) The endocannabinoid system and the regulation of neural development: Potential implications in psychiatric disorders. Eur. Arch. Psych. Neurosci. 259, 371-382. 2009 Salazar, M., Carracedo, A., Salanueva, I., Hernández, S., Blázquez, C., Lorente, M., Egia, A., Vázquez, P., Torres, S., Nowak, J., Fimia, G.M., Piacentini, M., Cecconi, F., Pandolfi, P.P., González-Feria, L., Iovanna, J.L., Guzmán, M., Boya, P. & Velasco, G. (2009) Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 119, 1359-1372. 2008 Galve-Roperh, I., Aguado, T., Palazuelos, J. & Guzmán, M. (2008) Mechanisms of control of neuron survival by the endocannabinoid system. Curr. Pharm. Des. 14, 2279-2288. 2008 Caffarel, M.M., Moreno-Bueno, G., Cerutti, C., Palacios, J., Guzmán, M., Mechta-Grigoriou, F. & Sánchez, C. (2008) JunD is involved in the antiproliferative effect of Δ9-tetrahydrocannabinol on human breast cancer cells. Oncogene 27, 5033-5044. 2008 Mulder, J., Aguado, T., Barabás, K., Ballester-Rosado, C.J., Nguyen, L., Monory, K., Keimpema, E., Marsicano, G., Di Marzo, V., Hurd, Y.L., Guillemot, F., Mackie, K., Lutz, B., Guzmán, M., Chen Lu, H.M., Galve-Roperh, I. & Harkany, T. (2008) Endocannabinoid signaling controls pyramidal cell specification and longe-range axon patterning. Proc. Natl. Acad. Sci. USA 105, 8760-8765. 2008 Palazuelos, J., Davoust, N., Julien, B., Hatterer, E., Aguado, T., Mechoulam, R., Benito, C., Romero, J., Silva, A., Guzmán, M., Nataf, S. & Galve-Roperh, I. (2008) The CB2 cannabinoid receptor controls myeloid progenitor trafficking: Involvement in the pathogenesis of an animal model of multiple sclerosis. J. Biol. Chem. 283, 13320-13329. 2008 Blázquez, C., Salazar, M., Carracedo, A., Lorente, M., Egia, A., González-Feria. L., Haro, A., Velasco, G. & Guzmán, M. (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68, 1945-1952. 2008 Blázquez, C., Carracedo, A., Salazar, M., Lorente, M., Egia, A., González-Feria. L., Haro, A., Velasco, G. & Guzmán, M. (2008) Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 54, 235- 243. 2007 Velasco, G., Carracedo, A., Blázquez, C., Lorente, M., Aguado, T., Haro, A., Sánchez, C., Galve-Roperh, I. & Guzmán, M. (2007) Cannabinoids and gliomas. Mol. Neurobiol. 36, 60-67. 2007 Harkany, T. Guzmán, M., Galve-Roperh, I. Berghuis, P., Devi, L. & Mackie, K. (2007) The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol. Sci. 28, 83-92. 2007 Galve-Roperh, I., Aguado, T., Palazuelos, J. & Guzmán, M. (2007) The endocannabinoid system and neurogenesis in health and disease. Neuroscientist 13, 109-114. 2007 Fernández-Ruiz, J., Romero, J., Velasco, G., Tolón, R.M., Ramos, J.A. & Guzmán, M. (2007) Cannabinoid CB2 receptor: a new target for the control of neural cell survival? Trends Pharmacol. Sci. 28, 39-45. 2007 Aguado, T., Romero, E., Monory, K., Sendtner, M., Marsicano, G., Lutz, B., Guzmán, M. & Galve-Roperh, I. (2007) The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. J. Biol. Chem. 282, 23892-23898. 2007 Aguado, T., Carracedo, A., Julien, B., Velasco, G., Milman, G., Mechoulam, R., Álvarez, L., Guzmán, M. & Galve-Roperh, I. (2007) Cannabinoids inhibit glioma stem-like cell differentiation and inhibit gliomagenesis. J. Biol. Chem. 282, 6854-6862. 2006 Galve-Roperh, I., Aguado, T., Rueda, D., Velasco, G. & Guzmán, M. (2006) Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development. Curr. Pharm. Des. 12, 2319-2325. 2006 Blázquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. & Guzmán, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635. 2006 Palazuelos, J., Aguado, T., Egia, A., Mechoulam, R., Guzmán, M. & Galve-Roperh, I. (2006) Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J. 20, 2405-2407. 2006 Lo Verme, J., Guzmán, M., Gaetani, S. & Piomelli, D. (2006) Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. J. Biol. Chem. 281, 22815-22818. 2006 Guzmán, M., Duarte, M.J., Blázquez, C., Ravina, J., Rosa, M.C., Galve-Roperh, I., Sánchez, C., Velasco, G. & González-Feria, L. (2006) A pilot clinical study of D9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br. J. Cancer 95, 197-203. 2006 Carracedo, A., Gironella, M., Lorente, M., García, S., Guzmán, M., Velasco, G. & Iovanna, J.L. (2006) Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res. 66, 6748-6755. 2006 Caffarel, M.M., Sarrió, D., Palacios, J., Guzmán, M. & Sánchez, C. (2006) D9-tetrahydrocannabinol inhibits human breast cancer cell cycle by down- regulating Cdc2. Cancer Res. 66, 6615-6621. 2006 Kogan, N.M., Blázquez, C., Álvarez, L., Gallily, R., Schlesinger, M., Guzmán, M. & Mechoulam, R. (2006) A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells. Mol. Pharmacol. 70, 51-59. 2006 Herrera, B., Carracedo, A., Diez-Zaera, M., Gómez del Pulgar, T., Guzmán, M. & Velasco, G. (2006) The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Exp. Cell Res. 312, 2121-2131. 2006 Carracedo, A., Lorente, M., Egia, A., Blázquez, C., Garcia, S., Giroux, V., Malicet, C., Villuendas, R., Gironella, M., González-Feria, L., Piris, M.A., Iovanna, J.L., Guzmán, M. & Velasco, G. (2006) The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9, 301-312. 2006 Carracedo, A., Egia, A., Guzmán, M. & Velasco, G. (2006) p8 Upregulation sensitizes astrocytes to oxidative stress. FEBS Lett. 580, 1571-1575. 2006 Aguado, T., Palazuelos, J., Monory, K., Stella, N., Cravatt, B., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M. & Galve-Roperh, I. (2006) The endocannabinoid system promotes astroglial differentiation by acting on neural progenitors. J. Neurosci. 26, 1551-1561. 2005 Velasco, G., Galve-Roperh, I., Sánchez, C., Blázquez, C., Haro, A. & Guzmán, M. (2005) Cannabinoids and ceramide: two lipids acting hand- by-hand. Life Sci. 77, 1723-1731. 2005 Herrera, B., Carracedo, A., Diez-Zaera, M., Guzmán, M. & Velasco, G. (2005) p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukemia cells. FEBS Lett. 579, 5084-5088. 2005 Aguado, T., Monory, K., Palazuelos, J., Stella, N., Cravatt, B., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M. & Galve-Roperh, I. (2005) The endocannabinoid system drives neural progenitor proliferation. FASEB J. 19, 1704-1706. 2005 Ramírez, B.G., Blázquez, C., Gómez del Pulgar, T., Guzmán, M. & de Ceballos, M.L. (2005) Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. 25, 1904-1913.
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