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2015 Pérez-Gómez, E., Andradas, C., Caffarel, M.M., Blasco-Benito, S., García-Taboada, E., Villa-Morales, M., Moreno, E., Hamann, S., Martín-Villar, E., Flores, J.M., Wenners, A., Alkatout, I., Klapper, W., Röcken, C., Bronsert, P., Stickeler, E., Staebler, A., Bauer, M., Arnold, N., Soriano, J., Pérez-Martínez, M., Megías, D., Moreno-Bueno, G., Ortega- Gutiérrez, S., Artola, M., Vázquez-Villa, H., Quintanilla, M., Fernández-Piqueras, J., Canela, E.I., McCormick, P.J., Guzmán, M. & Sánchez, C. (2015) Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer. J. Natl. Cancer Inst. 107, djv077. 2,58MB
2015 Blázquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., García-Rincón, D., Sendtner, M., Timmusk, T., Lutz, B., Galve-Roperh, I., & Guzmán, M. (2015) The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ. (Epub) 2,60MB
2015

Garcez, P.P., Diaz-Alonso, J., Crespo-Enriquez, I., Castro, D., Bell, D., Guillemot, F.(2015) Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1. Nat. Commun. (Epub)

3,65MB
2015

Morales, P., Blasco-Benito, S., Andradas, C., Gómez-Cañas, M., Flores, J.M., Goya, P., Fernández-Ruiz, J.J., Sánchez,* C., & Jagerovic,* N. (*co-corresponding authors) (2015) A selective, non-toxic CB2 cannabinoid o-quinone with in vivo activity against triple negative breast cancer. J. Med. Chem. (Epub)

1,22 MB
2015 Salazar, M., Lorente, M., García-Taboada, M., Pérez Gómez, E., Dávila, D., Zúñiga-García, P., Flores, J.M., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E. & Velasco, G. (2015) Loss of tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death Differ. 22, 131-144. 2,61 MB
2014 Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P. & Harkany, T. (2014) Programming of neural cells by (endo-)cannabinoids: from physiological rules to emerging therapies. Nat. Rev. Neurosci. 15, 787-804. 1,82MB
2014

Moreno, E., Andradas, C., Medrano, M., Caffarel, M.M., Pérez-Gómez, E., Blasco-Benito, S., Gómez-Cañas, M., Pazos, M.R., Irving, A.J., Lluís, C., Canela, E.I., Javier Fernández-Ruiz, J., Guzmán, M., McCormick, P.J. & Sánchez, C. (2014) Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. J. Biol. Chem. 289, 21960-21972.

4979 KB
2014

Chiarlone, A., Bellocchio, L., Blázquez, C., Resel, E., Soria-Gómez, E., Cannich, A., Ferrero, J.J., Sagredo, O., Benito, C., Romero, J., Sánchez-Prieto, J., Lutz, B., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M. (2014) A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc. Natl. Acad. Sci. USA 111, 8257–8262.

1,09 MB
2014

Díaz-Alonso, J., Aguado, T., de Salas-Quiroga, A., Ortega, Z., Guzmán, M. & Galve-Roperh, I. (2014) CB1 cannabinoid receptor-dependent activation of mTORC1/Pax6 signaling drives Tbr2 expression and basal progenitor expansion in the developing mouse cortex. Cereb. Cortex (Epub)

3,57 MB
2014 Soria-Gómez, E., Bellocchio, L., Reguero, L., G. Lepouse, Martin, C., Bendahmane, M., Ruehle, S., Remmers, F., Desprèz, T., Matias, I., Wiesner, T., Cannich, A., Wadleigh, A., Pape, H.P., Chiarlone, A.P., Quarta, C., Verrier, D., Vincent, P., Massa, F., Lutz, B., Guzmán, M., Gurden, H., Ferreira, G., Lledo, P.M., Grandes, P. & Marsicano, G. (2014) The endocannabinoid system controls food intake via olfactory processes. Nat. Neurosci. 17, 407-415 1,45 MB
2013 Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J.,  Bari, M., Guzmán, M., Maccarrone, M. (2013) Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Prog. Lipid Res. 52, 633-650. 3.5 MB
2013 Pérez-Gómez, E., Andradas, C., Flores, J.M., Quintanilla, M., Paramio, J.M., Guzmán, M. & Sánchez, C. (2013) The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas. Oncogene 32, 2534-2542. 3,7 MB
2013 Casarejos, M.J., Perucho. J., Gómez, A., Muñoz, M.P., Fernández-Estévez, M., Sagredo, O., Fernández Ruiz, J., Guzmán, M., García de Yébenes, J. & Mena, M.A. (2013) Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. J. Alzheimers Dis. 35, 525–539 792 KB
2013 Bellocchio, L., Soria-Gómez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E., Cannich, A., Delamarre, A., Häring, M., Martín-Fontecha, M., Vega, D., Bartsch, D., Monory, K., Lutz, B., Chaouloff, F., Pagotto, U., Guzmán, M., Cota, D. & Marsicano, G. (2013) Activation of the sympathetic nervous system mediates hypophagic and anxiety-related effects of CB1 receptor blockade. Proc. Natl. Acad. Sci. USA 110, 4786-4791. 874 KB
2013 Campos, A.C., Ortega, Z., Palazuelos, J., Fogaça, M.V., Aguiar, D.C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Henar, S., Moreira F.A., Guzmán, M., Galve-Roperh, I. & Guimarães, F.S. (2013) The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int. J. Neuropsychopharmacol. 16, 1407-1419. 217 KB
2013 Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Dávila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E. & Velasco, G. (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochim. Biophys. 1831, 1573-1578 665 KB
2012 Díaz-Alonso, J., Aguado, T., Wu, C., Palazuelos, J., Hofmann, C. Garcez, P., Guillemot, F., Lu, H., Lutz, B., Guzmán, M. & Galve-Roperh, I. (2012) The CB1 Cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J. Neurosci. 32, 16651-16665. 8 MB
2012 Bañez-Coronel, M., Porta, S., Kagerbauer, B., Mateu-Huertas, E., Pantano, L., Ferrer, I., Guzmán, M., Estivill, X. & Martí, E. (2012) A pathogenic mechanism in Huntington´s disease involves small CAG- Repeated RNAs with neurotoxic activity. PLoS Genet. 8. 2 MB
2012 Velasco, G., Sánchez, C. & Guzmán, M. (2012) Towards the use of cannabinoids as antitumour agents. Nat. Rev. Cancer 12, 436-444. 917 KB
2012 Caffarel, M., Andradas, C., Pérez-Gómez, E., Guzmán, M. & Sánchez,C. (2012)   Cannabinoids: A new hope for breast cancer therapy?. Cancer Treat. Rev. 38, 911-918. 780 KB
2012 Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. (2012) Endocannabinoids via CB1 receptors act as neurogenic niche cues during  cortical development. . 367, 3229-3241. 1.43 MB
2012

Palazuelos, J., Ortega, Z., Díaz-Alonso, J., Guzmán, M. & Galve-Roperh, I. (2012) CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling. J. Biol. Chem. 287, 1198-1209.

3,1 MB
2011 Henstridge, C.M., Balenga, N.A., Kargl, J., Andradas, C., Brown, A.J., Irving, A., Sanchez, C. & Waldhoer, M. (2011) Recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55. Mol. Endocrinol. 11, 1835-1848. 671 KB
2011

Salazar, M., Hernández-Tiedra, S., Torres, S., Lorente, M., Guzmán, M. & Velasco, G. (2011)  Detecting autophagy in response to ER stress signals in cancer. Methods Enzymol. 489, 297-317.

1,9 MB
2011 Vara, D., Salazar, M., Olea-Herrero, N., Guzmán, M., Velasco, G. & Díaz-Laviada, I. (2011) Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ.18, 1099-1111. 2.1 MB
2011

Lorente, M., Torres, S., Salazar, M., Carracedo, A., Hernández-Tiedra, S., Rodríguez-Fornés, F., García-Taboada, E., Meléndez, B., Mollejo, M., Campos-Martín, Y., Lakatosh,  S.A., Barcia, J., Guzmán, M. & Velasco, G. (2011) Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy mediated cell death. Autophagy 7, 1071-1073.

466 KB
2011

Lorente, M., Torres, S., Salazar. M., Carracedo, A., Hernández-Tiedra, S., Rodríguez-Fornés, F., García-Taboada, E., Meléndez, B., Mollejo, M., Campos-Martín, Y., Lakatosh, S.A., Barcia, J., Guzmán, M. & Velasco, G. (2011) Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ. 18, 959-973.

1,2 MB
2011

Torres, S., Lorente, M., Rodríguez-Fornés, F., Hernández-Tiedra, S., Salazar. M., García-Taboada, E., Barcia, J., Guzmán, M. & Velasco, G. (2011) A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol. Cancer Ther. 10, 90-103.

3 MB
2011 Blázquez, C., Chiarlone, A., Sagredo, O., Aguado, T., Pazos, M.R., Resel, E., Palazuelos. J., Julien, B., Salazar, M., Börner, C., Benito, C., Carrasco, C., Diez-Zaera, M., Paoletti, P., Díaz-Hernández, M., Ruiz, C., Sendtner, M., Lucas, J.J., De Yébenes, J.G., Marsicano, G., Monory, K., Lutz, B., Romero, J., Alberch, J., Ginés, S., Kraus, J., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M. (2011) Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain 134, 119-136. 1,1MB
2011

Andradas, C., Caffarel, M.M., Pérez-Gómez E., Salazar M. , Lorente M.,  Velasco G., Guzmán, M. & Sánchez C. (2011) The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK. Oncogene 30, 245-252.

586 KB
2010

Caffarel, M.M , Andradas, C., Mira, E., Pérez-Gómez, E., Cerutti, C., Moreno-Bueno, G., Flores, J.M., García-Real, I., Palacios, J., Mañes, S., Guzmán, M. & Sánchez, C. (2010) Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol. Cancer  9, 196-197.

982 KB
2010 Guzmán, M. (2010) A new age for MAGL. Chem. Biol. 17, 4-6.  313 KB
2010 Barana, A., Amorós, I., Caballero, R., Gómez, R., Osuna, L., Lillo, M.P., Blázquez, C., Guzmán, M., Delpón, E. & Tamargo, J. (2010) Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner. Cardiovasc. Res. 85, 56-67. 760 KB
2009 Palazuelos, J., Aguado, T., Pazos, M.R., Julien, B., Carrasco, C., Resel, E., Sagredo, O., Benito, C., Romero, J., Azcoitia, I., Fernández-Ruiz, J., Guzmán, M. & Galve-Roperh, I. (2009) Microglial CB2 cannabinoid receptors are neuroprotective in Huntington´s disease excitotoxicity. Brain 132, 3152-3164. 1751 KB
2009 Oesch, S., Walter, D., Wachtel, M., Pretre, K., Salazar, M., Guzmán, M., Velasco, G. & Schäfer, B.W. (2009) Cannabinoid receptor 1 is a potential drug targefor treatment of translocation-positive rhabdommyosarcoma. Mol. Cancer Ther. 8, 1838-1845. 391 KB
2009 Lorente, M., Carracedo, A., Torres, S., Natali, F., Egia, A., Blázquez, C., Hernández, S., Guzmán, M. & Velasco, G. (2009) Amphiregulin renders glioma cells resistant to cannabinoid-induced apoptosis. Glia 57, 1374-1385. 786 KB
2009 Galve-Roperh, I., Palazuelos, J., Aguado, T. & Guzmán, M. (2009) The endocannabinoid system and the regulation of neural development: Potential implications in psychiatric disorders. Eur. Arch. Psych. Neurosci. 259, 371-382. 299 KB
2009 Salazar, M., Carracedo, A., Salanueva, I., Hernández, S., Blázquez, C., Lorente, M., Egia, A., Vázquez, P., Torres, S., Nowak, J., Fimia, G.M., Piacentini, M., Cecconi, F., Pandolfi, P.P., González-Feria, L., Iovanna, J.L., Guzmán, M., Boya, P. & Velasco, G. (2009) Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 119, 1359-1372. 1892 KB
2008 Galve-Roperh, I., Aguado, T., Palazuelos, J. & Guzmán, M. (2008) Mechanisms of control of neuron survival by the endocannabinoid system. Curr. Pharm. Des. 14, 2279-2288. 2427 KB
2008 Caffarel, M.M., Moreno-Bueno, G., Cerutti, C., Palacios, J., Guzmán, M., Mechta-Grigoriou, F. & Sánchez, C. (2008) JunD is involved in the antiproliferative effect of Δ9-tetrahydrocannabinol on human breast cancer cells. Oncogene 27, 5033-5044.

686 KB

2008 Mulder, J., Aguado, T., Barabás, K., Ballester-Rosado, C.J., Nguyen, L., Monory, K., Keimpema, E., Marsicano, G., Di Marzo, V., Hurd, Y.L., Guillemot, F., Mackie, K., Lutz, B., Guzmán, M., Chen Lu, H.M., Galve-Roperh, I. & Harkany, T. (2008) Endocannabinoid signaling controls pyramidal cell specification and longe-range axon patterning. Proc. Natl. Acad. Sci. USA 105, 8760-8765. 2955 KB
2008 Palazuelos, J., Davoust, N., Julien, B., Hatterer, E., Aguado, T., Mechoulam, R., Benito, C., Romero, J., Silva, A., Guzmán, M., Nataf, S. & Galve-Roperh, I. (2008) The CB2 cannabinoid receptor controls myeloid progenitor trafficking: Involvement in the pathogenesis of an animal model of multiple sclerosis. J. Biol. Chem. 283, 13320-13329. 836 KB
2008 Blázquez, C., Salazar, M., Carracedo, A., Lorente, M., Egia, A., González-Feria. L., Haro, A., Velasco, G. & Guzmán, M. (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68, 1945-1952. 596 KB
2008 Blázquez, C., Carracedo, A., Salazar, M., Lorente, M., Egia, A., González-Feria. L., Haro, A., Velasco, G. & Guzmán, M. (2008) Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 54, 235- 243. 1200 KB
2007 Velasco, G., Carracedo, A., Blázquez, C., Lorente, M., Aguado, T., Haro, A., Sánchez, C., Galve-Roperh, I. & Guzmán, M. (2007) Cannabinoids and gliomas. Mol. Neurobiol. 36, 60-67. 192 KB
2007 Harkany, T. Guzmán, M., Galve-Roperh, I. Berghuis, P., Devi, L. & Mackie, K. (2007) The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol. Sci. 28, 83-92. 1209 KB
2007 Galve-Roperh, I., Aguado, T., Palazuelos, J. & Guzmán, M. (2007) The endocannabinoid system and neurogenesis in health and disease. Neuroscientist 13, 109-114. 583 KB
2007 Fernández-Ruiz, J., Romero, J., Velasco, G., Tolón, R.M., Ramos, J.A. & Guzmán, M. (2007) Cannabinoid CB2 receptor: a new target for the control of neural cell survival? Trends Pharmacol. Sci. 28, 39-45. 656 KB
2007 Aguado, T., Romero, E., Monory, K., Sendtner, M., Marsicano, G., Lutz, B., Guzmán, M. & Galve-Roperh, I. (2007) The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. J. Biol. Chem. 282, 23892-23898. 481 KB
2007 Aguado, T., Carracedo, A., Julien, B., Velasco, G., Milman, G., Mechoulam, R., Álvarez, L., Guzmán, M. & Galve-Roperh, I. (2007) Cannabinoids inhibit glioma stem-like cell differentiation and inhibit gliomagenesis. J. Biol. Chem. 282, 6854-6862. 749 KB
2006 Galve-Roperh, I., Aguado, T., Rueda, D., Velasco, G. & Guzmán, M. (2006) Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development. Curr. Pharm. Des. 12, 2319-2325. 107 KB
2006 Blázquez, C., Carracedo, A., Barrado, L., Real, P.J., Fernández-Luna, J.L., Velasco, G., Malumbres, M. & Guzmán, M. (2006) Cannabinoid receptors as novel targets for the treatment of melanoma. FASEB J. 20, 2633-2635. 1397 KB
2006 Palazuelos, J., Aguado, T., Egia, A., Mechoulam, R., Guzmán, M. & Galve-Roperh, I. (2006) Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J. 20, 2405-2407. 584 KB
2006 Lo Verme, J., Guzmán, M., Gaetani, S. & Piomelli, D. (2006) Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. J. Biol. Chem. 281, 22815-22818. 301 KB
2006 Guzmán, M., Duarte, M.J., Blázquez, C., Ravina, J., Rosa, M.C., Galve-Roperh, I., Sánchez, C., Velasco, G. & González-Feria, L. (2006) A pilot clinical study of D9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Br. J. Cancer 95, 197-203. 271 KB
2006 Carracedo, A., Gironella, M., Lorente, M., García, S., Guzmán, M., Velasco, G. & Iovanna, J.L. (2006) Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res. 66, 6748-6755. 604 KB
2006 Caffarel, M.M., Sarrió, D., Palacios, J., Guzmán, M. & Sánchez, C. (2006) D9-tetrahydrocannabinol inhibits human breast cancer cell cycle by down- regulating Cdc2. Cancer Res. 66, 6615-6621. 810 KB
2006 Kogan, N.M., Blázquez, C., Álvarez, L., Gallily, R., Schlesinger, M., Guzmán, M. & Mechoulam, R. (2006) A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells. Mol. Pharmacol. 70, 51-59. 986 KB
2006 Herrera, B., Carracedo, A., Diez-Zaera, M., Gómez del Pulgar, T., Guzmán, M. & Velasco, G. (2006) The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Exp. Cell Res. 312, 2121-2131. 752 KB
2006 Carracedo, A., Lorente, M., Egia, A., Blázquez, C., Garcia, S., Giroux, V., Malicet, C., Villuendas, R., Gironella, M., González-Feria, L., Piris, M.A., Iovanna, J.L., Guzmán, M. & Velasco, G. (2006) The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9, 301-312. 965 KB
2006 Carracedo, A., Egia, A., Guzmán, M. & Velasco, G. (2006) p8 Upregulation sensitizes astrocytes to oxidative stress. FEBS Lett. 580, 1571-1575. 257 KB
2006 Aguado, T., Palazuelos, J., Monory, K., Stella, N., Cravatt, B., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M. & Galve-Roperh, I. (2006) The endocannabinoid system promotes astroglial differentiation by acting on neural progenitors. J. Neurosci. 26, 1551-1561. 876 KB
2005 Velasco, G., Galve-Roperh, I., Sánchez, C., Blázquez, C., Haro, A. & Guzmán, M. (2005) Cannabinoids and ceramide: two lipids acting hand- by-hand. Life Sci. 77, 1723-1731. 170 KB
2005 Herrera, B., Carracedo, A., Diez-Zaera, M., Guzmán, M. & Velasco, G. (2005) p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukemia cells. FEBS Lett. 579, 5084-5088. 284 KB
2005 Aguado, T., Monory, K., Palazuelos, J., Stella, N., Cravatt, B., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M. & Galve-Roperh, I. (2005) The endocannabinoid system drives neural progenitor proliferation. FASEB J. 19, 1704-1706. 1220 KB
2005 Ramírez, B.G., Blázquez, C., Gómez del Pulgar, T., Guzmán, M. & de Ceballos, M.L. (2005) Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. 25, 1904-1913. 522 KB

 

 

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